Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]
33 mg
1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)
25 mg
6%
Top Medical Research Studies
8
We examined the relationship between vitamin B6 intake and kidney stone formation in women. This research involved over 85,000 women with no prior history of kidney stones, monitored over 14 years. The study utilized food-frequency questionnaires to track participants' dietary vitamin consumption from both food and supplements.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Read More
9
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
Read More
8
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Read More
Most Useful Reviews
9
Effective vitamin B6
11 people found this helpful
This active form of vitamin B6 helps me relax and enhances my mood. Additionally, it prevents the formation of kidney stones and bile stones. If oxalates are already present, it's crucial to take R-5-R urgently! You can safely take it long-term, increasing the dosage to 100 mg per day. Vitamin B6, when combined with magnesium citrate and sodium ascorbate, dissolves oxalate stones or sand in the kidneys. By taking 300 mg/day, I can monitor my urine. Furthermore, it lowers histamine levels and aids with seasonal allergies, along with other health benefits.
Read More
9
Restorative properties
P-5-P is an excellent formation for aiding kidney restoration and helps in the removal of sand.
Read More
7.5
Kidney stone relief
Excellent form of B6, particularly beneficial after dealing with kidney stones.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
- All Researches
9
The study examined the potential of pyridoxamine, a derivative of vitamin B6, in reducing kidney stones and oxalate excretion in conditions known as hyperoxaluria. The researchers aimed to find an effective treatment that would lower urine oxalate levels, which contribute significantly to kidney stone formation.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
Read More
9
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
Read More
8
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Read More
8
We explored the relationship between vitamin B6, also known as pyridoxine, and kidney stone formation, specifically in patients with primary hyperoxaluria type 1 (PH1). This condition arises from a deficiency in the enzyme alanine:glyoxylate aminotransferase (AGT), crucial for breaking down certain compounds in the liver. Among PH1 patients, about one-third have shown a clinical response to pharmacological doses of pyridoxine, especially those carrying specific AGT mutations.
To investigate this further, we utilized a cell-based cytotoxicity assay involving CHO cells expressing glycolate oxidase (GO) and various AGT variants. This setup allowed us to measure how well these AGT variants could counteract the toxic effects of glycolate, a compound that contributes to kidney stone formation. We observed that normal AGTs helped reduce the levels of harmful oxalate and glyoxylate, which are byproducts of glycolate, effectively improving cell survival.
Moreover, we found that increasing extracellular pyridoxine concentrations—up to 0.3μM—enhanced the metabolic effectiveness of normal AGTs and the variant AGT-Gly170Arg. This enhancement was associated with a significant reduction in oxalate and glyoxylate levels, directly linking vitamin B6's role to improved management of the metabolic processes involved in kidney stone formation.
Overall, our findings support the idea that vitamin B6 can improve the functionality of AGT, thus potentially offering a therapeutic route for managing PH1 and its associated kidney stone risks. This research not only enhances our understanding of PH1 but also opens avenues for developing better treatments for kidney stone diseases in general.
To investigate this further, we utilized a cell-based cytotoxicity assay involving CHO cells expressing glycolate oxidase (GO) and various AGT variants. This setup allowed us to measure how well these AGT variants could counteract the toxic effects of glycolate, a compound that contributes to kidney stone formation. We observed that normal AGTs helped reduce the levels of harmful oxalate and glyoxylate, which are byproducts of glycolate, effectively improving cell survival.
Moreover, we found that increasing extracellular pyridoxine concentrations—up to 0.3μM—enhanced the metabolic effectiveness of normal AGTs and the variant AGT-Gly170Arg. This enhancement was associated with a significant reduction in oxalate and glyoxylate levels, directly linking vitamin B6's role to improved management of the metabolic processes involved in kidney stone formation.
Overall, our findings support the idea that vitamin B6 can improve the functionality of AGT, thus potentially offering a therapeutic route for managing PH1 and its associated kidney stone risks. This research not only enhances our understanding of PH1 but also opens avenues for developing better treatments for kidney stone diseases in general.
Read More
8
Magnesium and Vitamin B6 prevent stones
We investigated the impact of magnesium salts, particularly magnesium L-aspartate and magnesium chloride, and their combination with vitamin B6 in preventing the formation of calcium oxalate kidney stones. In a controlled animal study, a specific diet high in sodium oxalate was used to induce kidney stone development.
Over the course of the study, we observed that rats treated with various magnesium salts showed a significant reduction in urinary oxalate levels—by about 45%. Furthermore, these treatments were linked to an increase in creatinine clearance, indicating improved kidney function. The ratio of calcium to magnesium also decreased, which is a positive outcome regarding stone formation.
Notably, when magnesium L-aspartate and MagneB6 were compared with other magnesium salts, they emerged as the most effective in preventing kidney stone formation. Our findings highlight the potential of combining vitamin B6 with magnesium as a promising strategy to mitigate calcium oxalate nephrolithiasis.
Over the course of the study, we observed that rats treated with various magnesium salts showed a significant reduction in urinary oxalate levels—by about 45%. Furthermore, these treatments were linked to an increase in creatinine clearance, indicating improved kidney function. The ratio of calcium to magnesium also decreased, which is a positive outcome regarding stone formation.
Notably, when magnesium L-aspartate and MagneB6 were compared with other magnesium salts, they emerged as the most effective in preventing kidney stone formation. Our findings highlight the potential of combining vitamin B6 with magnesium as a promising strategy to mitigate calcium oxalate nephrolithiasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective vitamin B6
11 people found this helpful
This active form of vitamin B6 helps me relax and enhances my mood. Additionally, it prevents the formation of kidney stones and bile stones. If oxalates are already present, it's crucial to take R-5-R urgently! You can safely take it long-term, increasing the dosage to 100 mg per day. Vitamin B6, when combined with magnesium citrate and sodium ascorbate, dissolves oxalate stones or sand in the kidneys. By taking 300 mg/day, I can monitor my urine. Furthermore, it lowers histamine levels and aids with seasonal allergies, along with other health benefits.
Read More
9
Restorative properties
P-5-P is an excellent formation for aiding kidney restoration and helps in the removal of sand.
Read More
7.5
Kidney stone relief
Excellent form of B6, particularly beneficial after dealing with kidney stones.
Read More
Frequently Asked Questions
9
Effective vitamin B6
11 people found this helpful
This active form of vitamin B6 helps me relax and enhances my mood. Additionally, it prevents the formation of kidney stones and bile stones. If oxalates are already present, it's crucial to take R-5-R urgently! You can safely take it long-term, increasing the dosage to 100 mg per day. Vitamin B6, when combined with magnesium citrate and sodium ascorbate, dissolves oxalate stones or sand in the kidneys. By taking 300 mg/day, I can monitor my urine. Furthermore, it lowers histamine levels and aids with seasonal allergies, along with other health benefits.
9
Restorative properties
P-5-P is an excellent formation for aiding kidney restoration and helps in the removal of sand.
7.5
Kidney stone relief
Excellent form of B6, particularly beneficial after dealing with kidney stones.
8
We explored the connection between vitamin B6 intake and the prevalence of kidney stones through a large-scale analysis of health data. Our research included data from the National Health and Nutrition Examination Survey (NHANES), where we looked at the effects of nine common vitamins on kidney stone development. By using advanced clustering techniques and logistic regression models, we aimed to identify patterns that could shed light on this relationship.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
Our findings revealed that higher intake levels of vitamin B6 were associated with a reduced risk of developing kidney stones. Specifically, the results indicated that participants with high vitamin B6 intake showed a significant decrease in kidney stone prevalence, which highlights the potential protective effect of this vitamin.
Moreover, we noted a similar beneficial trend with vitamin D intake, while the effects of vitamin C appeared more complex, initially suggesting a protective role before eventually turning into a risk factor at higher intake levels. This multifaceted analysis emphasizes the importance of considering vitamin combinations, as the collective intake of several vitamins also contributed to lower risks of kidney stone formation.
In summary, our findings suggest that ensuring proper levels of vitamin B6, along with a balanced intake of other essential vitamins, may play a crucial role in kidney stone prevention.
4
Our study looked into how vitamin B6 and magnesium supplementation could influence urinary oxalate levels, which are important in the formation of calcium oxalate (CaOx) kidney stones. We designed a trial involving 164 patients with a history of CaOx stones and recent diagnoses of idiopathic hyperoxaluria. These participants were divided into three treatment groups: one group followed a low-oxalate diet, another received vitamin B6 and magnesium supplements, and the last group combined both approaches.
After three months, we measured changes in urinary oxalate levels and found notable differences among the groups. The low-oxalate diet group showed a significant reduction of about 31.1% in urinary oxalate, while the vitamin B6 and magnesium supplementation group only decreased by 16.0%. The combined group experienced a 23.9% reduction, which was not significantly better than the diet alone. This suggests that while vitamin B6 has some role, it did not outperform the dietary approach.
We also noted that a high percentage of those on the low-oxalate diet saw improvements in their oxalate levels, reinforcing the diet's effectiveness. Importantly, there were no significant adverse effects reported from any of the treatment plans. This leads us to conclude that a low-oxalate diet is more effective than just relying on vitamin B6 and magnesium supplements for lowering urinary oxalate in those with kidney stones. More research is needed to determine long-term benefits and recurrence rates of kidney stones with these strategies.
After three months, we measured changes in urinary oxalate levels and found notable differences among the groups. The low-oxalate diet group showed a significant reduction of about 31.1% in urinary oxalate, while the vitamin B6 and magnesium supplementation group only decreased by 16.0%. The combined group experienced a 23.9% reduction, which was not significantly better than the diet alone. This suggests that while vitamin B6 has some role, it did not outperform the dietary approach.
We also noted that a high percentage of those on the low-oxalate diet saw improvements in their oxalate levels, reinforcing the diet's effectiveness. Importantly, there were no significant adverse effects reported from any of the treatment plans. This leads us to conclude that a low-oxalate diet is more effective than just relying on vitamin B6 and magnesium supplements for lowering urinary oxalate in those with kidney stones. More research is needed to determine long-term benefits and recurrence rates of kidney stones with these strategies.
7
We examined how vitamin B6, also known as pyridoxine, can influence oxalate levels in patients with type I primary hyperoxaluria—a condition that leads to kidney stones due to high oxalate in the urine. Our analysis focused on the effects of B6 treatment, revealing that responses can vary widely among individuals.
In our review of 23 patients, we specifically looked for responses to vitamin B6 based on genetic testing for the c.508 allele. It turned out that those with the c.508 G>A allele had a more favorable response to vitamin B6, experiencing notable reductions in urine oxalate levels. Doses of around 5 mg/kg/day of vitamin B6 appeared to be effective for these patients.
This finding suggests that genetic testing for the c.508 allele could help predict how a patient might respond to vitamin B6 treatment, guiding more personalized care. However, for patients without this specific allele, the effectiveness of B6 treatment may not be as pronounced.
In our review of 23 patients, we specifically looked for responses to vitamin B6 based on genetic testing for the c.508 allele. It turned out that those with the c.508 G>A allele had a more favorable response to vitamin B6, experiencing notable reductions in urine oxalate levels. Doses of around 5 mg/kg/day of vitamin B6 appeared to be effective for these patients.
This finding suggests that genetic testing for the c.508 allele could help predict how a patient might respond to vitamin B6 treatment, guiding more personalized care. However, for patients without this specific allele, the effectiveness of B6 treatment may not be as pronounced.
7
In our investigation, we aimed to see how a combination of Phyllanthus niruri extract, magnesium, and vitamin B6 could help treat uncomplicated kidney stones. Our study involved 48 patients, all of whom had stones confirmed to be under 15 mm in size. Over a three-month period, we monitored how this treatment affected the stones through imaging.
We found that most patients were around 48 years old, and they typically had a small number of stones averaging 5.5 mm in size. Surprisingly, the results indicated that while the treatment helped some patients, the effectiveness varied significantly based on the size and location of the stones. Specifically, stones that were 3 mm or smaller, especially those in the upper or middle parts of the kidneys, showed the best response to treatment.
However, we did not find a strong correlation between treatment success and other factors like patient gender or the side of the kidney where the stones were located. In fact, only 40% of the stones completely disappeared after the treatment, while another 21.7% shrank. This leaves us with the understanding that vitamin B6, while potentially beneficial, works best in conjunction with other factors and may not be a standalone solution for everyone.
Overall, our study highlights the mixed efficacy of combining vitamin B6 with other treatments and points out that a longer treatment duration might yield even better results in the future.
We found that most patients were around 48 years old, and they typically had a small number of stones averaging 5.5 mm in size. Surprisingly, the results indicated that while the treatment helped some patients, the effectiveness varied significantly based on the size and location of the stones. Specifically, stones that were 3 mm or smaller, especially those in the upper or middle parts of the kidneys, showed the best response to treatment.
However, we did not find a strong correlation between treatment success and other factors like patient gender or the side of the kidney where the stones were located. In fact, only 40% of the stones completely disappeared after the treatment, while another 21.7% shrank. This leaves us with the understanding that vitamin B6, while potentially beneficial, works best in conjunction with other factors and may not be a standalone solution for everyone.
Overall, our study highlights the mixed efficacy of combining vitamin B6 with other treatments and points out that a longer treatment duration might yield even better results in the future.
8
We examined the relationship between vitamin B6 intake and kidney stone formation in women. This research involved over 85,000 women with no prior history of kidney stones, monitored over 14 years. The study utilized food-frequency questionnaires to track participants' dietary vitamin consumption from both food and supplements.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.
On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
References
- Zeng H, Liu Z, He Y, Chen H, He J, et al. Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study. Int Urol Nephrol. 2024;56:2991. 10.1007/s11255-024-04021-9
- Gupta M, Gallante B, Bamberger JN, Khusid JA, Parkhomenko E, et al. Prospective Randomized Evaluation of Idiopathic Hyperoxaluria Treatments. J Endourol. 2021;35:1844. 10.1089/end.2021.0122
- Cealan A, Coman RT, Simon V, Andras I, Telecan T, et al. Evaluation of the efficacy of standardized extract combined with magnesium and vitamin B6 for the treatment of patients with uncomplicated nephrolithiasis. Med Pharm Rep. 2019;92:153. 10.15386/mpr-1246
- Yang H, Male M, Li Y, Wang N, Zhao C, et al. Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster. BMC Nephrol. 2018;19:167. 10.1186/s12882-018-0980-8
- Fargue S, Knight J, Holmes RP, Rumsby G, Danpure CJ. Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay. Biochim Biophys Acta. 2016;1862:1055. 10.1016/j.bbadis.2016.02.004
- Spasov AA, Iezhitsa IN, Kharitonova MV, Kravchenko MS, Snigur GL, et al. [Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor]. Patol Fiziol Eksp Ter. 2013.
- Scheinman JI, Voziyan PA, Belmont JM, Chetyrkin SV, Kim D, et al. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol Res. 2005;33:368.
- Monico CG, Rossetti S, Olson JB, Milliner DS. Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant allele. Kidney Int. 2005;67:1704.
- Nakatani T, Ishii K, Yoneda Y, Kamikawa S, Kanazawa T, et al. The preventive effect of sodium pentosan polysulfate against renal stone formation in hyperoxaluric rats. Urol Res. 2002;30:329.
- Di Tommaso L, Tolomelli B, Mezzini R, Marchetti M, Cenacchi G, et al. Renal calcium phosphate and oxalate deposition in prolonged vitamin B6 deficiency: studies on a rat model of urolithiasis. BJU Int. 2002;89:571.
- Li S, Wu C, Nong H, Deng Y. [Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization]. Zhonghua Wai Ke Za Zhi. 1998;36:763.
- Curhan GC. Epidemiologic evidence for the role of oxalate in idiopathic nephrolithiasis. J Endourol. 1999;13:629.
- Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol. 1999;10:840.
- Selvam R, Ravichandran V. Restoration of tissue antioxidants and prevention of renal stone deposition in vitamin B6 deficient rats fed with vitamin E or methionine. Indian J Exp Biol. 1993;31:882.
- Grimm U, Steinhauser I, Wulff K, Knapp A, Zschiesche M. [Studies on tryptophan metabolism in calcium oxalate urolithiasis]. Z Urol Nephrol. 1988;81:299.
